TissueSeal was founded in 2003 and is a provider of medical/surgical products in the United States.  TissueSeal, in collaboration with B. Braun and its U.S. subsidiary Aesculap, achieved regulatory approval in February 2007 for the sale and distribution of its Histoacryl® topical skin adhesive.  With the introduction of Histoacryl® to the U.S. market, TissueSeal is able to offer an outstanding, proven alternative to other legally marketed topical skin adhesives.  The TissueSeal management team has been serving the medical device industry collectively for over 85 years.  TissueSeal maintains its headquarters in Ann Arbor, Michigan.